Last update date: October 11, 2023

Hesperetin is a flavonoid found in lemons and sweet oranges. It is a cholesterol lowering flavonoid.

Frequently Asked Questions


What is Hesperetin?

Hesperetin is a natural compound belonging to the flavanones subgroup of flavonoids. It is predominantly found in citrus fruits like oranges, grapefruits, lemons, and tangerines. Scientific research has highlighted the antioxidant and anti-inflammatory properties of hesperetin. Given that chronic diseases, including heart disease, are closely linked to inflammation, researchers have been keenly investigating the potential benefits of hesperetin supplementation.


What is positive impact of Hesperetin?

Anti-Inflammatory Properties: Hesperetin exhibits anti-inflammatory effects that may help mitigate chronic inflammation, a known contributor to diseases like heart disease. Antioxidant Properties: Hesperetin acts as an antioxidant, assisting your body in neutralizing harmful free radicals and protecting cells from oxidative damage. Anticancer Properties: Preliminary studies suggest that hesperetin may have anticancer potential by inhibiting the growth of cancer cells. Antimicrobial Properties: Hesperetin possesses antimicrobial properties that may aid in combating certain infections. Anti-Glaucoma Properties: Hesperetin's properties may be beneficial in managing conditions like glaucoma, a group of eye diseases.


What is negative impact of Hesperetin?

While hesperetin is generally safe, some hesperetin products have reported potential side effects, including: Abdominal Pain: In some cases, hesperetin supplements may lead to abdominal discomfort. Contact Dermatitis: Contact with hesperetin in its pure form might cause an itchy rash known as contact dermatitis. Diarrhea: Diarrhea is another possible side effect associated with hesperetin consumption. Nausea: Some individuals may experience nausea after taking hesperetin supplements. It's important to note that clinical studies assessing hesperetin's efficacy for conditions like high blood pressure, hemorrhoidal disease, type 2 diabetes, and liver disease have not reported any significant side effects.


Who should avoid Hesperetin?

Certain individuals should exercise caution or avoid hesperetin supplementation altogether. This includes: Pregnant or Breastfeeding Individuals: Hesperetin's effects during pregnancy and breastfeeding are not well understood, so it's advisable for expectant or nursing mothers to avoid it. Anemia: If you have anemia, a condition characterized by a lack of healthy red blood cells, hesperetin supplementation may not be suitable. History of Brain Bleeding: Individuals with a history of bleeding in the brain should steer clear of hesperetin supplements. Bleeding in the Urinary or Gastrointestinal Tract: If you've experienced bleeding in the urinary or gastrointestinal tract within the past three weeks, hesperetin supplementation may not be advisable.


What are common sources of Hesperetin?

Hesperetin can be naturally sourced from various citrus fruits, including: Lemons Limes Mandarins Oranges Grapefruits However, it's worth noting that the absorption and metabolism of hesperetin can vary depending on the form of citrus fruit. For instance, studies have shown that hesperetin from orange juice is more readily absorbed than that from whole oranges. Therefore, the way you consume citrus fruits can influence the availability of hesperetin in your body.

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